Irapp horse3/4/2023 ![]() This same thing has been shown in people, as well as in experimental models in horses. The horses that responded tended to have higher levels of I-1 in their ACS than did the horses that didn’t respond. In 2019, a study of 20 horses (which is not a lot, but that’s the way things often go in horse medicine) found that just over half of the treated horses responded to injection with IRAP/ACS. But that’s not the whole story.Īs with many things scientific, there’s still a lot to be learned. One study in horses, as well as a study of 376 people with osteoarthritis of the knee, have each concluded that it’s an effective treatment for joint inflammation. Of course, being a horse owner, and wondering if you should use the product in your horse, you’re really interested in one question: “How effective is it?” Well, here’s where things get a little sticky. When needed, it’s thawed, and injected into inflamed areas, including joints, in and around tendons, and into the uterus of female horse’s too (it’s being tried to help mares with reproductive problems). The serum is filtered to weed out any bacteria, and then frozen into doses for later use. Following incubation, the syringe is centrifuged, and 20 – 25 ml of IRAP serum is collected (enough for 5 – 6 doses). ![]() The syringe is then incubated for 24 hours. ![]() To start the process, blood is drawn into a special syringe containing glass beads coated with a substance that enhances the production of anti-inflammatory proteins, including IRAP. In the 1990’s, a German biochemist found that the white blood cells that normally circulate in your horse’s bloodstream could be stimulated to producethe IRAP protein. Thus, IRAP helps prevent interleukin-1 from contributing to joint inflammation.Ī clever bit of biochemistry is responsible for IRAP. When I-1 can’t bind, it doesn’t work very well. Essentially, IRAP plugs up the receptor site, and leaves the I-1 without a home. So, in sum, IRAP is a protein that works by binding to the receptor site on the joint capsule where the inflammatory protein interleukin-1 binds. S which is the horse’s own (autologous) blood serum, serum being the liquid that makes up blood after the cells and some of the protein has been removed. The protein in IRAP binds to the receptor where I-1 binds, and acts to antagonize the activity of I-1.Ī stands for autologous, which means that it comes from the horse’s own body.Ĭ stands for conditioned, which means that you have to do something to the… Proteins are any of a huge group of nitrogen-containing compounds that are essential components of life. An antagonist to anything offers opposition to that thing. For interleukin-1 to work, it has to bind to a special receptor-site in the joint capsule that lines the joint.Ī stands for antagonist. I-1 levels are increased in joint inflammation (arthritis). Interleukins are a group of protein molecules that are involved in the process of inflammation. Supplements An “alternative” industry that is worth billions of dollars to manufacturers – and worth about nothing to the horse.Ī Civil War Battery of Horse Drawn Artillery.But they do not help tissues heal, and have not for hundreds of year. Homeopathy For more than 200 years, homeopathy has failed to demonstrate that it is anything more than water.Would you give unknown amounts of unknown substances to your horse? The problem – from a medicine point of view – is that they haven’t been very effective, for a variety of reasons. Herbal Medicine Herbs and plants have been used as medicine for centuries.Chiropractic First devised in the late 1800s by an ex-grocer, chiropractic still has not shown it is worth.Alternative Medicine Resources Good information which you can use to help separate fact from fiction.Acupuncture There is more misinformation about acupuncture than just about any other thing in the horse world.Wounds Proper attention to your horse’s wounds can help ensure a successful outcome. ![]()
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